ACJ joint Extra Strength

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SCIENCE

ACJ joint Extra Strength
Research and Summary Comments

Hyaluronic acid

1. Hyaluronic acid compared with corticosteroid injections for the treatment of osteoarthritis of the knee: a randomized control trial.

Osteoarthritis (OA) is the most common chronic condition of the joints that takes place when the cartilage or a low friction surface between joints breaks down which leads to pain, stiffness and swelling. The purpose of the present study was to evaluate the therapeutic effect of intra-articular hyaluronic acid (HA) in comparison to corticosteroids (CS) for knee osteoarthritis.

140 patients with knee osteoarthritis, who were followed for 3 months, were randomized to receive intra-articular injection of either hyaluronic acid or corticosteroid. By receiving one injection of drug during the enrollment in the study, the patients were treated. With the Western Ontario and McMaster University Osteoarthritis Index (WOMAC), Knee injury and Osteoarthritis Outcome Score (KOOS), and the visual analog pain scale, an independent, blinded evaluator assessed the patients three times.

The mean age of the patients in the corticosteroid group were 57 ± 1.9 years and in Hyaluronic acid group were 58.5 ± 8.3 years. WOMAC score represented that pain and stiffness did not improve in neither groups at any time points after intervention (P > 0.05). KOOS score suggested that symptoms improved after 3 months in both CS and HA groups. Besides, daily activity improved in both groups (P < 0.05). As a conclusion, it is argued that the most important difference between the two intervention groups is the duration of effectiveness. HA is suggested to be superior in the duration of pain relief when compared to CS. We can propose that HA can be administered every 3 months intra-articular for knee joint OA. Therefore, when CS has to be injected every 2 months, it will be more convenient to use HA. Takeaway:
• HA was superior to CS injection in terms of reduced duration of pain in patients with knee osteoarthritis.

2. Effect of hyaluronic acid on chondrocyte apoptosis.

The purpose of the study was to determine the percentage of apoptotic cells in a contusion model of osteoarthritis (OA) and to assess whether intra-articular injection of high doses of hyaluronic acid (HA) immediately after trauma reduces chondrocyte apoptosis.

Forty knees from adult rabbits were impacted thrice with a 1 kg block released through a 1 meter tall cylinder (29.4 Joules). Subsequently, 2 mL of HA was injected in one knee and 2 mL saline in the contra-lateral knee. Medication were administered twice a week for 30 days, when animals were sacrificed. Specimens were prepared for optical microscopy exam and terminal deoxynucleotidyl transferase end labeling assay (TUNEL).

The apoptosis rate in the contusion model was 68.01% (± 19.73%), a higher rate than previously described. HA significantly reduced the rate of apoptosis to 53.52% (± 18.09) (p <0.001). Takeaway:

• Administration of HA may be effective in reducing chondrocyte apoptosis immediately following trauma/injury.

Collagen

3. A randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort.

Current options to promote joint comfort are limited to medicines that can reduce pain but can also have adverse effects. Collagen, a major component of joint cartilage, is found in the diet, particularly in meat. Its hydrolysed form, collagen hydrolysate (CH), is well absorbed. CH may stimulate the joint matrix cells to synthesize collagen, so helping to maintain the structure of the joint and potentially to aid joint comfort.

In a randomized, double-blind, controlled multicentre trial, 250 subjects with primary osteoarthritis of the knee were given 10 g CH daily for 6 months.

There was a significant improvement in knee joint comfort as assessed by visual analogue scales to assess pain and the Womac pain subscale. Subjects with the greatest joint deterioration, and with least intake of meat protein in their habitual diets, benefited most. CH is safe and effective and warrants further consideration as a food ingredient.
Takeaway:
• Supplementation with Collagen is a safe and effective means of addressing osteoarthritic pain/discomfort, particularly, in this study with patients having the greatest levels of joint deterioration.

4. Collagen hydrolysate for the treatment of osteoarthritis and other joint disorders: a review of the literature.

There is a need for an effective treatment for the millions of people in the United States with osteoarthritis (OA), a degenerative joint disease. The demand for treatments, both traditional and non-traditional, will continue to grow as the population ages.

According to published research, orally administered collagen hydrolysate has been shown to be absorbed intestinally and to accumulate in cartilage. Collagen hydrolysate ingestion stimulates a statistically significant increase in synthesis of extracellular matrix macromolecules by chondrocytes (p < 0.05 compared with untreated controls). These findings suggest mechanisms that might help patients affected by joint disorders such as OA. Four open-label and three double-blind studies were identified and reviewed; although many of these studies did not provide key information--such as the statistical significance of the findings--they showed collagen hydrolysate to be safe and to provide improvement in some measures of pain and function in some men and women with OA or other arthritic conditions. Takeaway:

• Verifies the point made in the previous study, that Collagen is an effective means of helping patients with joint disorders. Here, specific mention of how it achieves this is noted: a significant increase in synthesis of extracellular matrix macromolecules by chondrocytes.

Glucosamine

5. Glucosamine-containing supplement improves locomotor functions in subjects with knee pain: a randomized, double-blind, placebo-controlled study.

The aim of this study was to investigate the ability of a glucosamine-containing supplement to improve locomotor functions in subjects with knee pain. Japanese Knee Osteoarthritis Measure, visual analog scale score, normal walking speed, and knee-extensor strength were measured to evaluate the effects of the supplement on knee-joint functions and locomotor functions.

A randomized, double-blind, placebo-controlled, parallel-group comparative study was conducted for 16 weeks in 100 Japanese subjects (age, 51.8±0.8 years) with knee pain. Subjects were randomly assigned to one of the two supplements containing 1) 1,200 mg of glucosamine hydrochloride, 60 mg of chondroitin sulfate, 45 mg of type II collagen peptides, 90 mg of quercetin glycosides, 10 mg of imidazole peptides, and 5 μg of vitamin D per day (GCQID group, n=50) or 2) a placebo (placebo group, n=50). Japanese Knee Osteoarthritis Measure, visual analog scale score, normal walking speed, and knee-extensor strength were measured to evaluate the effects of the supplement on knee-joint functions and locomotor functions.
In subjects with mild-to-severe knee pain at baseline, knee-extensor strength at week 8 (104.6±5.0% body weight vs 92.3±5.5% body weight, P=0.030) and the change in normal walking speed at week 16 (0.11±0.03 m/s vs 0.05±0.02 m/s, P=0.038) were significantly greater in the GCQID group than in the placebo group. Further subgroup analysis based on Kellgren-Lawrence (K-L) grade showed that normal walking speed at week 16 (1.36±0.05 m/s vs 1.21±0.02 m/s, P<0.05) was significantly greater in the GCQID group than in the placebo group in subjects with K-L grade I. No adverse effect of treatment was identified in the safety assessment. Takeaway:

• Glucosamine, in the presence of the other, synergistic ingredients, produced improvements in both knee pain and walking speed in patients with knee pain.

6. Efficacy and safety of glucosamine, diacerein, and NSAIDs in osteoarthritis knee: a systematic review and network meta-analysis.

The objective was to conduct a systematic review and network meta-analysis of randomized controlled trials (RCTs) with the aims of comparing relevant clinical outcomes (that is, visual analog scores (VAS), total and sub-Western Ontario and McMaster Universities Osteoarthritis index (WOMAC) scores, Lequesne algofunctional index, joint space width change, and adverse events) between diacerein, glucosamine, and placebo.

Compared to placebo, glucosamine showed a significant improvement with unstandardized mean differences (UMD) in total WOMAC, pain WOMAC, function WOMAC, and Lequesne score of -2.49 (95% confidence interval (CI) -4.14, -0.83), -0.75 (95% CI: -1.18, -0.32), -4.78 (95% CI: -5.96, -3.59), and -1.03 (95% CI: -1.34, -0.72), respectively. Diacerein clinically improves visual analog scores, function WOMAC, and stiffness WOMAC with UMD values of -2.23 (95% CI: -2.82, -1.64), -6.64 (95% CI: -10.50, -2.78), and -0.68 (95% CI: -1.20, -0.16) when compared to placebo.

The network meta-analysis suggests that diacerein and glucosamine are equally efficacious for symptom relief in knee OA, but that the former has more side effects.
Takeaway:
• Glucosamine provided levels of symptom relief similar to that shown with Diacerein (slow-acting medicine of the class anthraquinone used to treat joint disorders), but with fewer side effects.

Turmeric Herb (Curcuma longa)

7. Safety and efficacy of Curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial.

The clinical examination of affected joint was measured by an orthopaedic specialist and using a Clinician Global Impression Change (CGIC) scale. The analysis of post-treatment scores following administration of NR-INF-02 (Curcuma longa) using VAS, WOMAC, and CGIC at each clinical visit showed significant decrease (p < 0.05) compared to placebo. NR-INF-02 treated group showed a significant (p < 0.01) decrease in use of rescue medication, along with clinical and subjective improvement compared to placebo. The tolerability and acceptability profile of NR-INF-02 was better during the trial period. The study demonstrates safety and efficacy of NR-INF-02 as a useful treatment option for patients with primary painful knee OA. Takeaway:
• Curcumin is a safe and effective means of addressing bothersome symptoms related to osteoarthritis.

8. Anti-inflammatory effect of Curcuma longa (turmeric) on collagen-induced arthritis: an anatomico-radiological study.

The main aim of the study was to observe the inflammatory, macroscopic and radiological changes in the arthritic ankle joints of experimentally collagen-induced arthritis animals treated with or without CL extract.

Treatment with 110 mg/ml/kg CL showed significant mean difference in the ESR (p<0.01), AS (p<0.05) and radiological scores (p<0.01) on day-28 compared to the vehicle treated group. The administration of CL extract arrested the degenerative changes in the bone and joints of collagen-induced arthritic rats. Takeaway:
• In this study, Curcumin was proven effective in counteracting degenerative bone and joint changes related to arthritis.

Boswellia serrata (Olibanum indicum)

9. FlexiQule (Boswellia extract) in the supplementary management of osteoarthritis: a supplement registry.

The aim of the present pilot, registry study was an assessment in a supplement study of FlexiQule (standardized Boswellia extract) capsules in the supplementary management of patients with symptomatic knee osteoarthritis (OA) also treated with the “standard management” (SM) in comparison with a group of patients only managed with SM. Twenty-seven registry subjects using the supplement+SM and 28 using only SM completed the registry; at inclusion, the two groups were comparable including Karnofsky scale, WOMAC Score and the Treadmill Test.

The Karnofski Scale at 4 weeks was improved in both groups: from 74.3;3.1 to 88.9;5.3 (P<0.05) in the Boswellia group in comparison with a variation from 75.3;5.2 to 79.4;3.3 (P<0.05) in the SM. The effects of the supplement were significantly higher (P<0.05). Social/emotional functions improved better with the supplement (P<0.05). Both groups improved their walking distance at 4 weeks. The improvement was higher (P<0.05) in the Boswellia group. The need for other drugs or tests during the registry period was reduced more in the supplement group (P<0.05). The difference between SM and the supplementation associated to SM was significant) in favor of the supplementation with Boswellia for all target measurements evaluated in the registry at 4 weeks. Takeaway:
• Boswellia supplementation was more effective than “standard management” (SM) therapies in addressing osteoarthritis symptoms, and required less intervention with drugs or testing during the study period.

Ginger root

10. Effects of a ginger extract on knee pain in patients with osteoarthritis.

Two hundred sixty-one patients with OA of the knee and moderate-to-severe pain were enrolled in a randomized, double-blind, placebo-controlled, multicenter, parallel-group, 6-week study. After washout, patients received ginger extract or placebo twice daily, with acetaminophen allowed as rescue medication. The primary efficacy variable was the proportion of responders experiencing a reduction in “knee pain on standing,” using an intent-to-treat analysis.

In the 247 evaluable patients, the percentage of responders experiencing a reduction in knee pain on standing was superior in the ginger extract group compared with the control group (63% versus 50%; P = 0.048). Analysis of the secondary efficacy variables revealed a consistently greater response in the ginger extract group compared with the control group, when analyzing mean values: reduction in knee pain on standing (24.5 mm versus 16.4 mm; P = 0.005), reduction in knee pain after walking 50 feet (15.1 mm versus 8.7 mm; P = 0.016), and reduction in the Western Ontario and McMaster Universities osteoarthritis composite index (12.9 mm versus 9.0 mm; P = 0.087).

A highly purified and standardized ginger extract had a statistically significant effect on reducing symptoms of OA of the knee.
Takeaway:
• Ginger root extract was effective in improving pain related to standing and after walking in patients with osteoarthritis of the knee.

Purple Passion fruit (Passiflora edulis)

11. Oral intake of purple passion fruit peel extract reduces pain and stiffness and improves physical function in adult patients with knee osteoarthritis.

The hypothesis tested in this study was that the passion fruit peel extract (PFP), a flavonoid-rich dietary supplement, would reduce symptoms due to knee OA. Thirty-three OA patients were enrolled in a randomized, double-blind, placebo-controlled trial with parallel-group design. Patients received either placebo or PFP pills (150 mg, daily) in a double-blinded fashion for 2 months.

The results of this study show that PFP substantially alleviated osteoarthritis symptoms. This beneficial effect of PFP may be due to its antioxidant and anti-inflammatory properties.
Takeaway:
• PFP, in this study, provided significant relief in patients with knee OA, likely driven by its antioxidant and anti-inflammatory properties.

Bornyl acetate (Amomum villosum)

12. Bornyl acetate has an anti-inflammatory effect in human chondrocytes via induction of IL-11.

Both pro-inflammatory cytokines and anti-inflammatory cytokines generated by chondrocytes play essential roles in the process of Rheumatoid arthritis and osteoarthritis (OA). Bornyl acetate is the main volatile constituent in numerous conifer oils and some Chinese traditional herbs, which has displayed an anti-inflammatory effect before. In this study, we found that bornyl acetate elevates the expression of IL-11 at both the mRNA and protein levels.

Interestingly, our results indicated that IL-1β-mediated up-regulation of IL-6, IL-8, MMP-1, and MMP-13 was significantly compromised by IL-11 co-treatment on mRNA levels and protein levels. The antagonistic effects of bornyl acetate on IL-1β induced targets MMP-1 and MMP-13 were diminished by IL-11 knockdown. Mechanistically, our results indicated that bornyl acetate significantly elevates the expression of AP-1 component c-fos, which may influence gross AP-1 activity and initial the transcription of IL-11. Indeed, expression of IL-11 was reversed upon c-fos knockdown.
Takeaway:
• Bornyl acetate has therapeutic potential in OA patients, primarily driven by elevated expression of IL-11 (cytokine related to osteoclast formation), as shown in this study.
Devil’s Claw Root (Harpagophytum procumbens)

13. Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes.

Harpagoside, one of the bioactive components of Harpagophytum procumbens (Hp), has been shown to possess anti-inflammatory properties. Here we used an in vitro model of inflammation in OA to investigate the potential of harpagoside to suppress the production of inflammatory cytokines/chemokines such as IL-6 and matrix degrading proteases.
We further investigated the likely targets of harpagoside in primary human OA chondrocytes. OA chondrocytes were pre-treated with harpagoside before stimulation with IL-1β. mRNA expression profile of 92 cytokines/chemokines was determined using TaqMan Human Chemokine PCR Array.
Taken together, the present study suggests that harpagoside exert a significant anti-inflammatory effect by inhibiting the inflammatory stimuli mediated by suppressing c-FOS/AP-1 activity in OA chondrocytes under pathological conditions.
Takeaway:
• Devil’s Claw Root shows promise as a potent anti-inflammatory agent and could prove useful in cases of joint disorders.

Citation links:

1. https://www.ncbi.nlm.nih.gov/pubmed/27104130
2. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3512263/
3. https://www.ncbi.nlm.nih.gov/pubmed/19212858
4. https://www.ncbi.nlm.nih.gov/pubmed/17076983
5. https://www.ncbi.nlm.nih.gov/pubmed/26604721
6. https://www.ncbi.nlm.nih.gov/pubmed/25889669
7. https://www.ncbi.nlm.nih.gov/pubmed/23242572
8. https://www.ncbi.nlm.nih.gov/pubmed/21717043
9. https://www.ncbi.nlm.nih.gov/pubmed/26076376
10. https://www.ncbi.nlm.nih.gov/pubmed/11710709
11. https://www.ncbi.nlm.nih.gov/pubmed/?term=Passiflora+edulis+joint+pain
12. https://www.ncbi.nlm.nih.gov/pubmed/25545915
13. https://www.ncbi.nlm.nih.gov/pubmed/27082319

DOSAGE GUIDELINES

Standard Dose

Take 6 sprays by mouth, twice daily.

Higher Dose

Take 12 sprays by mouth, twice daily.

Optimal Use

  • Spray, swish and swallow. You may take other Results RNA formulas immediately.
  • Do not eat or drink for 2 minutes following.
  • Take as recommended by your physician.
SUPPLEMENT FACTS

SERVING SIZE

Serving size: 12 Sprays

Servings Per Container (2oz/60mL): Approx. 30
Servings Per Container (4oz/120mL): Approx. 60

AMOUNT PER SERVING (2oz/60mL)
Proprietary Blend ~9000 mcg*

AMOUNT PER SERVING (4oz/120mL)
Proprietary Blend ~18000 mcg*

INGREDIENTS

Ingredients

Hyaluronic acid, Collagen, Glucosamine hydrochloride, Turmeric Herb (Curcuma longa), Boswellia serrata (Olibanum indicum), Ginger root, Purple Passion fruit (Passiflora edulis), Bornyl acetate (Amomum villosum), Tart Cherry Powder (Prunus Cerasus), Devil’s Claw Root (Harpagophytum procumbens), Peppermint Leaf (Mentha x piperita) and Natural Trace Minerals.

* % Daily value not established

BEST RESULTS

For Best Results:

Take ACJ Joint Extra Strength in combination with the Ultimate Body Detox System to achieve optimal joint and total body health.

Instant Absorption. Comprehensive Support
ACJ Joint Extra Strength provides immediate absorption of vital nutrients and comprehensive support, replenishing the health of your joints and muscles with a simple-to-take, great tasting spray.

Daily Benefit Without Side-Effects
Taking ACJ Joint Extra Strength daily provides significant OA relief, without adverse side effects or difficult to swallow capsules or pills.

Optimal Nourishment. Extraordinary Relief
Provides a synergistic blend of bioavailable nutrients targeting joints, muscles and cartilage at the cellular level.

2 oz $29.95
4 oz $49.95

Clinically Proven Results
Hundreds of clinical studies validate this exceptional formula, which includes Hyaluronic acid, Collagen, Glucosamine, Turmeric herb, Boswellia serrata, Ginger root, Purple Passion fruit, Bornyl acetate, Devil’s Claw root and synergistic mineral blends.

Antioxidant & Anti-inflammatory
ACJ Joint substantially alleviates OA symptoms; exerting anti-inflammatory and antioxidant effect.

Advanced Cellular Technology
ACJ Joint delivers the power of each ingredient in the most effective manner possible; achieving maximum results without stomach discomfort or side effects. With Advanced Cellular Technology, ACJ Joint Extra Strength Intra-oral spray is immediately absorbed, simple to take, and has a pleasant taste with a hint of natural mint. Just spray, swish, and swallow.

Joint Health Facts by Lyn Hanshew, M.D

Who Gets Osteoarthritis?

✓ Osteoarthritis occurs most often in older people

✓ Younger people sometimes get osteoarthritis primarily from joint injuries

What Typically Causes Osteoarthritis?

✓ Being overweight

✓ Getting older

✓ Joint injury

✓ Joints that are not properly formed

✓ Stresses on the joints from certain jobs and playing sports

What are the signs of osteoarthritis?

✓ Stiffness in a joint after getting out of bed or sitting for a long time

✓ Swelling or tenderness in one or more joints

✓ A crunching feeling or the sound of bone rubbing on bone

Purity and Quality Guaranteed:

gmp_logoACJ joint Extra Strength is produced under strict GMP manufacturing controls in conformance with guidelines for dietary supplements set forth in USP XXVII. For purity and quality, ACJ joint contains no preservatives • no alcohol • no artificial coloring or flavoring. For customer support, please call 1 888 823 3869.